慢性炎症促进神经胶质瘤生长微环境免疫抑

Chronicinflammationdrivesgliomagrowth:cellularandmolecularfactorsresponsibleforanimmunosuppressivemicroenvironmentEdwardTHa1,JosephPAntonios1,HoracioSoto1,RobertMPrins2,IsaacYang3,NoriyukiKasahara4,LindaMLiau2,CarolAKruse21DepartmentofNeurosurgery,DavidGeffenSchoolofMedicine,UniversityofCalifornia,LosAngeles,CA,USA2DepartmentofNeurosurgery,DavidGeffenSchoolofMedicine;BrainResearchInstitute;JonssonComprehensiveCancerCenter,UniversityofCalifornia,LosAngeles,CA,USA3DepartmentofNeurosurgery,DavidGeffenSchoolofMedicine;JonssonComprehensiveCancerCenter,UniversityofCalifornia,LosAngeles,CA,USA4DepartmentofMedicine,DavidGeffenSchoolofMedicine,UniversityofCalifornia,LosAngeles,CA,USA

CorrespondenceAddress:CarolAKruseDepartmentofNeurosurgery,DavidGeffenSchoolofMedicine,UniversityofCalifornia,GondaCenter,Box,MC,CharlesEYoungDriveSouth,LosAngeles,CAUSA

Abstract

Thisreviewexaminesgliomadiseaseinitiation,promotion,andprogressionwithafocusonthecelltypespresentwithinthetumormassandthemoleculesresponsiblefortheimmunosuppressivemicroenvironmentthatarepresentateachstepofthedisease.Thecelltypesandmoleculespresentalsocorrelatewiththegradeofmalignancy.Anoveralltype2chronicinflammatorymicroenvironmentdevelopsthatfacilitatesgliomapromotionandcontributestotheneo-vascularizationcharacteristicofgliomas.Animmunosuppressivemicroenvironmentshieldsthetumormassfromclearancebythepatientsownimmunesystem.Here,weprovidesuggestionstodealwithachronically-inflamedtumormicroenvironmentandprovidere







































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